Polymorphisms in the endothelial nitric oxide synthase gene associated with recurrent miscarriage
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چکیده
منابع مشابه
Polymorphisms in the endothelial nitric oxide synthase gene associated with recurrent miscarriage.
Endothelial nitric oxide synthase (eNOS) is an enzyme that influences placental human chorionic gonadotropin production during gestation. Previous studies have indicated an association between eNOS activity, implantation, and maintenance of pregnancy, but proposed associations between polymorphisms of the eNOS gene and recurrent miscarriage (RM) are controversial. To identify markers contributi...
متن کاملNitric oxide levels and endothelial nitric oxide synthase gene polymorphisms in Turkish women with idiopathic recurrent miscarriage.
OBJECTIVE To determine whether endothelial nitric oxide synthase (eNOS) gene polymorphisms are associated with an increased risk for Idiopathic Recurrent Miscarriage (IRM) in the Turkish population and to evaluate the association between Nitric Oxide (NO) levels and eNOS gene polymorphisms in women with IRM. MATERIAL AND METHODS A total of 120 Turkish women were enrolled in this study in four...
متن کاملEndothelial nitric oxide synthase gene polymorphism in women with idiopathic recurrent miscarriage.
BACKGROUND Lack of endothelium-derived nitric oxide is associated with vasospasm and vascular infarction. We investigated the relationship between idiopathic recurrent miscarriage and a polymorphism of the gene encoding endothelial nitric oxide synthase (NOS3). METHOD In a prospective case-control study, 105 women with idiopathic recurrent miscarriage and 91 healthy controls were investigated...
متن کاملComputational Prediction of the Effects of Single Nucleotide Polymorphisms of the Gene Encoding Human Endothelial Nitric Oxide Synthase
ABSTRACT Background and Objective: Genetic variations in the gene encoding endothelial nitric oxide synthase (eNOS) enzyme affect the susceptibility to cardiovascular disease. Identification of the way these changes affect eNOS structure and function in laboratory conditions is difficult and time-consuming. Thus, it seems essential to ...
متن کاملEndothelial nitric oxide synthase gene polymorphisms in giant cell arteritis.
OBJECTIVE To examine potential associations of the Glu/Asp(298) polymorphism in exon 7 and the 4a/b polymorphism in intron 4 of the endothelial nitric oxide synthase (eNOS) gene with susceptibility to and clinical expression of giant cell arteritis (GCA), particularly in patients with versus those without ischemic complications. METHODS Ninety-one consecutive patients with biopsy-proven GCA, ...
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ژورنال
عنوان ژورنال: Genetics and Molecular Research
سال: 2013
ISSN: 1676-5680
DOI: 10.4238/2013.september.23.6